Systems on chip, by definition, unite a number of functions and occasionally, sensors or actuators, into a unified, compact, lower-power solution to a signal processing problem. Recent efforts have seen the research, development, and commercialization of systems on chip that are sufficiently programmable and flexible to address a wider variety of applications and signal processing problems than their fixed configuration counterparts. In this paper, we present the application of a recently commercialized SoC effort to the problem of interrogating a low frequency radio frequency transponder, using an amplitude shift keyed encoding scheme. Within this representative application, the following reductions are realized compared to a discrete implementation: power 64%, cost 71%, component count 96%, and size 95%. In addition, the better matched components in the SoC provide a 25% improvement in read range over the discrete implementation of the radio frequency identification interrogator.